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Symbol
Name
ID

Vwf
Von Willebrand factor
MGI:98941

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes

Abnormal bleeding

Epistaxis

Spontaneous, recurrent epistaxis

Gingival bleeding

Gastrointestinal hemorrhage

Hematemesis

Joint hemorrhage

Menorrhagia

Persistent bleeding after trauma

Prolonged bleeding after dental extraction

Prolonged bleeding after surgery

Prolonged bleeding time

Bruising susceptibility

Purpura

Petechiae

Spontaneous hematomas

Abnormal bone marrow cell morphology

Abnormal megakaryocyte morphology

Increased megakaryocyte count

Increased micromegakaryocyte count

Increased multinucleated megakaryocyte count

Megakaryocyte nucleus hyperlobulation

Leukocytosis

Acute leukemia

Acute myeloid leukemia

Chronic myelogenous leukemia

Arterial thrombosis

Venous thrombosis

Hepatic vein thrombosis

Superficial thrombophlebitis

Reduced factor VIII activity

Impaired ristocetin-induced platelet aggregation

Reduced quantity of Von Willebrand factor

Reduced von Willebrand factor activity

Prolonged whole-blood clotting time

Abnormality of thrombocytes

Impaired platelet aggregation

Impaired ADP-induced platelet aggregation

Impaired collagen-induced platelet aggregation

Impaired epinephrine-induced platelet aggregation

Decreased platelet glycoprotein Ib-IX-V

Abnormal platelet morphology

Thrombocytopenia

Macrothrombocytopenia

Thrombocytosis

Giant platelets

Myelodysplasia

Splenomegaly

Disease(s) Associated with VWF

Behcet's disease

Bernard-Soulier syndrome

essential thrombocythemia

von Willebrand's disease 1

von Willebrand's disease 2

von Willebrand's disease 3

Mouse Phenotypes		increased hemoglobin content	thrombocytopenia	increased mean platelet volume	abnormal platelet physiology	abnormal platelet activation	abnormal platelet aggregation	decreased platelet aggregation
Availability	Mouse Genotype	increased hemoglobin content	thrombocytopenia	increased mean platelet volume	abnormal platelet physiology	abnormal platelet activation	abnormal platelet aggregation	decreased platelet aggregation
	Vwf^tm1.1Diac/Vwf^tm1.1Diac
	Vwf^tm1.1Geno/Vwf^tm1.1Geno
	Vwf^tm1.1Vhf/Vwf^tm1.1Vhf
	Vwf^tm1Wgr/Vwf^tm1Wgr
	Vwf^tm1.1Geno/Vwf⁺
	Vwf^tm1.1Vhf/Vwf⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23